Attached is my score. Didn't make it to the final boss, but was pretty close.
I got in a bad spot where I died and had to jump a landmine, kill a white coat coming down in a parachute, a bazooka guy and the normal baddies. You can jump over an enemy and what I do to give me some more time is when those 3 bad guys come from the right side of the screen, I kill 2 of them and then jump the 3rd. He finishes running across the screen before they come out again. This buys me another second or two when I need it.
I don't point press, but you do get twice as many points when you kill the bad guys with a weapon vs using your knife, so I make sure to use my weapon up. At the end of stage 1 when all the bad guys come from the truck, use your flame thrower to kill them.