My preferance is to decase. It exposes more air to the parts, which means cooler, which means that it lasts longer. Plus, I dropped 8 lbs of weight by decasing form the PC case. AND, it's easier to blow the dust off of the components. Dust is everywhere, and you'll have to take the computer out and open it up to clean the dust off.
THAT SAID, definitely consider what Paige says, too. He has a lot of experience. If you're stressing, just hook that case up. but why not try decasing?
Once you figure out how to secure everything your first time, it will be easy.