It is very dependent on the woofers in the enclosure. A 4x6 has a midrange/midbass woofer that probably doesn't extend much below 150 hz, so while the enclosure will help with that lower end, you won't gain much from it unless you can tune it to match the speaker. Those speakers are really designed to just work in a situation where you isolate the front from the back (ie infinite baffle). But isolating them from each other is not a bad idea.
Bottom line is that a small enclosure will help with bass but since you won't have any idea how to tune the enclosure to fit the speaker, all you can really do here is punt. You might end up with a spike at a frequency that makes it sound muddy, or you might end up with a nice boost in the lower frequencies. So don't make the enclosures too small, the bigger they are the less boost you will get but also the lower the frequency of the boost. A half cubic foot or more should be good. Just seal it up and don't even think about trying to port it. Add a little polyfill or Dacron behind the speakers to break up standing waves. Be careful with the bass because since the speakers are not designed to go very low in frequency, running full range to them with any amount of power can damage them. If you hear any distortion on music with a lot of bass, either turn it down or use some kind of equalization or crossover to dial down the bass. Under normal volumes this should sound just fine and have a little "punch" from the increased midbass.