I tried Makaron and I spent several days trying to get it working right and I couldn't figure out why everyone sang it's praises.
Again, I think it comes down to when you jumped into emulation.
If someone were coming into it now and their PC is capable, they should just use Demul.
The state of NAOMI games in Makaron was way ahead of Demul for a while.
It could also be launched fullscreen via command line so was front-end friendly.
It was the only way to play the arcade version of Marvel Vs Capcom 2 for a long while.
Makaron is weird in that it wasn't really ever made for distribution.
The dev just shared it on his blog every once in a while in whatever state it was in at the time.
Sometimes it wouldn't include all the files, sometimes the .ini files were only partially complete.
You almost had to be following along with his blog throughout the development and have used the previous version to know how to set it up.
My Makaron romset is a weird collection of .bin, .dat, & mame zips from the time. The mame zips work for some games, others require the .bin
Someone made an unauthorized UI version of it, but I didn't try it because it set my anti-virus software off.
I use it for a fair number of NAOMI games that my PC falls just short of running full speed on Demul. (mostly shmups that experience occasional slowdown in demul)
IIRC it doesn't have any screen rotation so if you don't have a rotating screen, you'll be playing them sideways.
He doesn't post as often as he used to, but his latest project might interest you.
http://dknute.livejournal.com/