Aside from games that need two joysticks, I can't see how angled sticks can affect game play. Like Donkbaca said, people put the stick towards the screen.... which is how the sticks are typically angled. Imagine a four player cab with all four players lined up in a row. Absurd, I say! Not aesthetically pleasing either, some kind of giant block mothership looking CP. Unless you are playing an angled set, specifically at an angle to the actual controller (parallel to the screen instead of in the angled cp location, like playing player 3, while in a player one spot... which is stupid, and by association makes you stupid.) then the angle really shouldn't be a factor. People didn't seem to have a problem playing gauntlet legends. Or am I mistaken in what this conversation is about?
Now, two stick games like smash TV, yes. Way yes. Difficult with an angled stick for two players. Perhaps impossible for a guest to get a hang of it in limited time (and why would they if there are so many other games to play). A single person, or two (like a roommate, I won't say wife because I'll go out on a limb and state that no wives like smash TV) could get the hang of it, but not a guest.