I did a jig with 1/4" MDF (after doing a few with guides and pencil lines) and it worked out pretty good. I used a guide collar on the router with a 1/4 upcut spiral bit. The slots in the jig are the same width as the collar I used. So I just clamp it in place, set the plunge depth on the router to about 1/4" below the bottom of the collar, run the router through the slots, blow out the dust, set the plunge depth another 1/4" deeper, rinse and repeat until done. The only problem with it is the dust clogs the slots fast and you sometimes have to stop, clear the dust, and finish the cuts. I made the guide the same way the slots are made in the post above, just with two passes with the 1/4" bit to get the width for the guide right.
In this pic, the left speaker grill is already done and the right one is just the jig clamped to the board. It is hard to see but the jig's slots are wider than the finished slots.
