Ok, i finally have my mame e6750 w/vista 64, 4 gig ram running on mame, 121.1, carnevil & mace run perfect, Gauntlet legends & blitz run good but they still have a slight sound jumping.  Taz how does blitz run on your 6850, & 121 have you noticed a slowdown if so i may go back to v120.  thanks for the help also i overclocked to 3.4
dm
Haven't noticed much change with 0.121, most of the big changes were in 0.121u# releases
gauntleg is about the same, runs fine speed wise but still likes to lock up at random.
blitz is down a little maybe 5%, I suck at this game totally so haven't tried in game lately. 
Good to see you've got your PC up and running well, and welcome to the fast lane. what heatsink are you using by the way?
Any new bench results with mame 121?
Full set of in game benchmarks, run in Vista 64bit, use MAMEUI 64bit, with the command line:
-noautoframeskip -frameskip 0 -seconds_to_run 240 -nothrottle -nosleep -video ddraw -skip_gameinfo -effect none -nowaitvsync -noreadconfig -mt [ROM NAME] 
- 1942                      0.121u1      6572.08%
- a51site4                0.121u1      235.35%
- airco22b                0.121u1      143.19%
- alpinerd                 0.121u1      88.50%
- biofreak                 0.121u1      145.12%
- blitz2k                   0.121u1      160.68%
- blitz99                   0.121u1      153.09%
- blitz                       0.121u1      167.30%
- calspeed                0.121u1      204.23%
- carnevil                  0.121u1      285.30%
- crusnusa                0.121u1      276.53%
- crusnwld                0.121u1      249.91%
- cybrcomm              0.121u1      135.27%
- Daytona                 0.121u1      212.79%
- gauntdl                  0.121u1      134.20%
-gauntleg                 0.121u1      159.81%
- gradius4                 0.121u1      96.85%       (64bit MAME /64bit Windows)
                                 0.121u1      110.77%      (32bit MAME /32bit Windows)      
                                 0.121u1      113.95%      (32bit MAME /64bit Windows)
- hyprdriv                  0.121u1      175.17%
- mace                      0.121u1      251.07%
- offroadc                  0.121u1      438.94%
- propcycl                  0.121u1      137.27%
- radikalb                  0.121u1      177.72%
- raveracw                0.121u1      121.21%
- ridgerac                  0.121u1      151.72%
- scud                        0.121u1      28.61%    (score keeps getting worse, but demo speed keeps getting better, can't wait for this one to be a working ROM)
- sfrush                     0.121u1      211.70%
- sidebs2                  0.121u1      215.90%
- speedup                 0.121u1      179.16%
- starblad                  0.121u1      145.58%
- surfplnt                   0.121u1      163.14%
- tenthdeg                 0.121u1      85.30%
- timecris                   0.121u1      145.30%
- wargods                 0.121u1      411.74%
- wg3dh                    0.121u1      375.54%
- xevi3dg                  0.121u1      371.37%
can you try a comparison to your regular benchmarks with the following in your Makefile ARCH= line ?
-march=nocona -mtune=nocona -minline-all-stringops -maccumulate-outgoing-args -mmmx -msse -msse2 -msse3 -mfpmath=sse -funroll-loops -fomit-frame-pointer 
and perhaps even compare that to 
-march=pentium-m -mtune=pentium-m -minline-all-stringops -maccumulate-outgoing-args -mmmx -msse -msse2 -msse3 -mfpmath=sse -funroll-loops -fomit-frame-pointer 
I've been really busy of late, but if I get a chance in the next few days I give it a go, mind you it will have to be a 32bit build, 64bit builds are still beyond me.