How do you set up mame and your front-end to switch the 360 configuration for 4 and 8 way games?
... new maps everytime you load a game. I believe that recent versions of Mame do that automatically (although I havent checked).
Almost the same, but different.

If your joystick is in analog mode, mame automatically applies a 9x9 analog-to-digital grid instead of what, but much like, u360 can do internally.
So mame doesn't
send u360 new maps, but does them instead.
Important:
only when the joystick is in analog mode, and if you want your own instead of mame's default maps, it's done differently than u360 mapping utility (best info how in mame's docs/config.txt).
Otherwise, yup.

(BTW, if you already have your FE setup to make the changes, just leave it as is. If you haven't setup up the u360 at all and you only use mame, leave the u360 in analog mode and let mame do the work. If use other emus, those switch maps plugins are the way to go. If you're somewhere in the middle [shrug] try both.)