What I don't like is PC games that ALMOST let you remap all the controls, but not quite. Like they have a few that are hardcoded, or have some keys that aren't allowed to be mapped.
My first button on my cab is enter, and my coin button sends escape. That lets me deal with most menus/frontends. but not all of them. particularly infuriating are Y/N prompts. I may reprogram 4-way so left sends Y and right sends N just to deal with that (Doom does that).
I recall at least one emulator that won't let you map return as a control.
My favorite PC games on the cabinet (Which has one 4-way, one 8-way 6 buttons, a trackball 2 start buttons and a coin/escape button) are,
Pod Racer - takes some getting used to to play this with an 8-way rather than an analog.
Frogger (New Version) Good old 4-way action!
Doom II (or maybe it is Final Doom, I dunno, I have some version of it).