unless you play alot of fighting games, you will mainly be using the top row of buttons. i made my control panel 12x30", my top row of buttons is 6" back from the front edge, which is enough room to rest my hand on the panel when using the top row, and having it just on the edge for using the bottom row. i don't play alot of fighting games, so it works out well. if i had a bigger panel, i'd probably move them back a little, but 12" deep seems to fit well with my cabinet.