I would follow the Golden Axe layout, because you will be compatible with a much greater number of platform games that way (Rygar, Black Tiger, Rolling Thunder, Shinobi, Shadow Dancer, Strider, etc, etc, etc)
With that layout, you keep your index finger hovered over B1, and your middle finger over B2, and then you only move your hand up to smash the "special skill" button (B3).
Then for DD, just remap the inputs.