I really like the look of cabs that don't have the control panel sticking out past the sides of the cabinets, but the Centipede style seems to be extremely narrrow and short. What are your plans for the panel?
Glad you asked! Four 8-ways, a 4-way, two trackballs, three spinners, 8 buttons per player and about 12 admin buttons scattered liberally.

I'm just kidding.
First off, my original plans was a four player panel. But then there was two-player Marble Madness. Then there were steering wheel games. Etc. Can't fit all that on a four player panel. And I also agree with you, I like the cabs that aren't spewing out from the sides better.
Basically I'm going the modular route ala Doc. The interior width (that is, not including the sides) is 25 inches, which means panels come in 6-1/4, 12-1/2, 18-3/4 or full 25 inch sizes (though, they'll mainly be of the first two varieties only). I'm working on a system that allows the panels to be secure and easy to remove without any visible over-hang. It's still in the experimental stage but I'm planning on having the front most piece push forward slightly (via a strong hinge I picked up) to provide the necessary lip to lift the panel off the latch (probably cabinet latches). There will be gaps most certainly, but I'm hoping the black exterior will hide it a bit. I'll be sure to be more specific as to the details if and when I get that perfected.
Though modular does help cut down on duplicate parts, I am consolidating certain panels for simplicity or necessity (e.g.. - the 8-way will be attached with the 7 button layout... buttons are cheap enough. Also, the trackball panels will have buttons since I can't fit a 3-inch trackball onto only a quarter panel).
Depth-wise the panels are 10 inches, though I'm losing about 2 inches up front and a little less than an inch in the back which is still more than enough space according to my measurements (the biggest footprint I measured was the 3 inch trackball at 6-1/2 inches). Obviously, the start buttons (and pause/shift) will be relegated to a simple, vertical panel underneath the monitor.
The cabinet style may or may not fit two players as comfortable as, say, Street Fighter II or Mortal Kombat cabinets, but it seems to be workable. It's going to be a one-player affair 90% of the time anyhow (which is why I scrapped my original 4-player setup).
Finally, if my measurements are acurate (and they probably aren't), I should be able to fit a 27 inch monitor in there.
So to make a long answer short - yup, there's more than enough space.
... I hope.
