To Krick and Tiger-Heli :
thank you thank you thank you thank you thank you thank you thank you !
I really appreciate the info and the speed of the responses! Perhaps someday I can contribute like you guys do. Hopefully I can put my 7 years in EE school to good use here

So to summarize:
Windows 98SE (with appropriate patches) no problemo for regular MAME w/ 2 trackballs simultaneously - or AdvanceMAME in Linux or in Win2k with CPNMouse.
Upon further studying, (including reading the gp-wiz49 thread), it appears there is some interest in getting a linux interface to this device working and RandyT is willing to work with them (that is awesome), but as of yet nothing has come of if - that I can find. So Windows it is for now.
one rephrasing of a question:
if I have plenty of button inputs from getting the GPwiz's - are there any reasons to go with the opti-pac?
Yes, specifically, no way to hook a trackball to a GPWiz49. Apples and Oranges - GPWiz49 equals gamepad hack, Opti-Pac equals mouse hack.
... oops - I should have clarified - no you are correct sir I may not hook up a trackball to gp-wiz49 ! But if I'm running 49 way sticks, and I go with one gp-wiz49 eco per stick (an obvious choice IMO) that means I will get 23 additional button inputs per gp-wiz49 (if I go w/ 4 sticks that's 92 buttons

) which is more than enough buttons - so with that in mind - it seems that the Opti pac is overkill with the additional buttons... also:
Tiger-Heli, I re-read the section on your controls page about the optical interfaces, as you suggested, and it seems that basically it comes down between Oscar's USB mouse i/f and the opti-pac. As far as I can tell through googling/etc. - Oscar's stuff is unavailable.
So if I found a couple USB mice that had different USB IDs (suggestions?) to hack would that be a comparable substitution for the Oscar product? Or, I suppose try plugging them in to different USB pairs like krick suggested.
Thanks again,
Rock