As long as you dont break any leads your all good..
one note of caution..
the G5 resin material that the board is made of is a carcinogen and acts like silica or glass in the lungs..This stuff embeds itself in there and never comes out

..this leads to the same types of problems that asbestos is associated with..nothing like dying from drowning in your own fluids!
in its solid state it is intert and safe to handle or put in your mouth if you so wished..
but the dust created by drilling milling or whatever is quite harmfull.
i recomend wet drilling .