I used Optix on my old driving cab and a 3/4 scale cab with a wide bezel that supported it well. I cut it on the table saw with a fine tooth blade.
It cuts fine as long as you don't stop long enough for it to heat up.
Lowe's would cut it to size for you last time I checked.
My current cab has thicker tinted plexi from the local glass shop. I don't know what material it is.
They cut it to size for me and it was fairly cheap because it was left over from some other job.
I'm always surprised by how cheap the local glass shop is. You should look into one in your area.
In my opinion, there are 2 main concerns:
1. Support - it doesn't work well if only supported on the edges unless it is perfectly vertical. It can droop if leaned back at an angle. Especially the thin stuff at the big box stores. If it is also supported by wide rigid layer such as bezel art would be attached to, it is fine. My current cab is only supported by 3/4" angle on the sides and bottom, but it is 1/4" thick and not leaned back too far. The driving cab was the thin 0.093" stuff from Lowe's, but it was perfectly vertical.
2. Scratching - I use pledge multi-surface wipes about once a month. I am careful to wipe across and not push the dust down against the surface. After years of this, there is an even coat of super fine scratches that are only noticeable when holding a bright light up to the surface to look for them. They aren't noticeable while playing or looking at the cab when turned off.
Not a definitive answer, but that is my experience with it.
My advice is to check with your local glass shop for a better and probably equally priced alternative.