I cannot see anything wrong with the layout. I like it. It has plenty of room for movement and expansion. I hope you factor in button reach while sitting, as it gets old standing at the cab for awhile.
It is you who is going to be using it, regardless if it had eleven admin buttons on it. You can always play around with button configuration at a later date.
Also I have to say that your woodwork is most excellent.

You definitely seem to have got a good handle on your vision, and I hope you will share pictures of the complete assembly.
The marquee, is better lighted with cold cathode tubes that you can hook up with your PC PSU. They come in 12 and 5 volts and provide adequate lighting. Activation can be done many ways, but I would go the simplest route and have it powered on during boot up.
Whatever you decide, will always be with some experiments. If you have any problems let us know, just ignore the trolls that try to wind you.
