Finally an update.  So thanks to everyone on here, I asked Dream Home Arcades to take another stab at my Street Fighter II Mame Pedestal.   The big issues we addressed were: 
1.  Button Spacing:  had them move them closer...now they are truly 1.5" center to center.  As you'll see from the before and after photos, I think this will be much better and make gameplay enjoyable, with no strain.   
2. Joysticks:  Moved them all closer to the buttons like Capcom had them.  And most importantly, players 3-4 are NO LONGER ANGLED.   Up on joystick is up on the screen.   Would never have known to ask for this without you guys, but it makes sense. 
3. 4-Way Joystick:  Just got rid of it all together.  It was in no man's land, disrupted the art, and I have a 60-1 Ms Pac Man for most of my 4-way games anyway, plus a dedicated Donkey Kong and Fix it Felix.  
4. Added black player select boxes like Capcom had "1 PLAYER, 2 PLAYERS, etc. 
I kept the track ball where it's at. It's going to be black, not white.  Also kept 6 buttons for players 3-4, sorry guys, just like the look even if it's extra, do nothing buttons. 
Lastly, I just want to say thank you so much for the insight and advice.   I was SO CLOSE to just having them ship the first build and living with it.  It's a hard pill to swallow, but I literally knew nothing about how to direct them with this build.  Now I know, thanks to everyone on here.   Please, share your comments and thoughts...I'll pass along more photos as they send them to me.