Ok, so I read about this in another forum (they build speaker cabinets out of MDF).
Yesterday I cut a master template for a bartop build I'm working on and wanted to seal the template from moisture and any wear and tear it might encounter. I used a mixture of equal parts wood glue and water. Painted a coat on with a foam brush making sure to really get the cut edges saturated. Let it dry and then reapplied a second coat. Finished up with a quick sanding using 220 grit paper.
I know time will tell if this method is a good way to preserve MDF from wear and tear. I am very pleased with the way it looks and feels. Very "Rock Solid".