sigh....these threads always seem to turn into lame arguments. Just to make it clear, the general catch for people to hate on angled joysticks is that people will instinctually press up towards the screen, instead of relative to them. This will cause funny angled controlling. I personally think that this is only sometimes the case, somy vote is option 3: figure it out for yourself. I'm gonna throw out the answer I always throw out:
I use straight joysticks. Always have, always will. I have tried angling my joysticks before on a test panel, and failed. I have also tried someone else's angled panel before that was well done, and was very surprised how well it played. People here have argued that there is absolutely, positively no exception to the straight rule, I now believe that there are exceptions. As long as the panel is made right, your mind will not be thrown off. I just am foggy on what makes a "well made angled Panel" Why did my attempt fail, but another one work? maybe size of panel, how clearly it was marked, distance from monitor??? I dunno.
No matter what, player 3 and 4 are generally on in there as a courtesy, and sometimes you just gotta fit the controls how they work the best. Nobody wants to be player 3 or 4. Those are the ---smurfette--- seats of the control panel. Whenever someone asks me these days, I just tell them to make a cardboard mock-up of their design and give it plenty of play time to test it from all players, before committing to angled or straight joysticks.
The real pros to straight joysticks is that it will get you games like smash TV, and the fact that straight joysticks seem to always work. The only con is that it can sometimes take more real estate to fit, and promote overly wide "Wing Panels"