yes, daisy chain black and red wires to all leds.
Are you talking about the molex plugs coming apart with screws? No, they dont work quite like that.
I always cut the molex plug off and wire directly to the wires. But if you dont want to do that, you can scrap some insulation off the wires. wrap the "new" wires around the scrapped part (good and tight, solder if you can), then wrap it up in some good tape. I have also used the "Y adapters" one male plug branching off to to female plugs, plug male Y plug into power molex plug, plug one of the female Y plugs into the hard drive and cut the other female Y one off and wire it to my other stuff. You can get these Y splitters or adapters at radio shack, im pretty sure. But if you have a spare molex you are not using, I would use that for the led power. If you cut the plug off, be sure to also tape the ends of the wires you are not using, dont want them to get against anything.