When I tried it, I found some subtle internal state data to become corrupted over time.
For instance, Aliens lost sound entirely; Xevious would lose the ability to move the ship right, and Galaga would start to glitch the positions of sprites and make collision detection errors.
That may have been ironed out in later Mame versions, or it might be something unique to my setup. Watch out for it though, it took me a while to notice it was even happening, and then to track it down.