Yes it runs full speed on my cabinet, however the version of mame I found compiled with 145u2 (some sort of mameui plus jobber), is an incredible resource hog. Takes several minutes to launch, won't close, eats 1/4th of the system ram, etc, etc and I only have one game installed.
Hit 400K my first game on factory settings. Definitely a huge difference. My high score on the multiboard version was near a million, but that was with sticks centered on a 19" screen (not in the player 1 slot on a 27") and I probably played several thousand games to get there.