Besides the CPU, the greatest heat generators are the Hard Drives. Whats
really bad about that... is that they usually are not well spaced, and the bottom drives
"Cook" the upper drives.
After losing several Top drives... Ive took a angle grinder to the case... and cut off most of
the front metal. Ive mounted 2 Industrial fans ( 4.5 inch diameter? ) in front.
I made my own custom drive mounting rail system, which permits about 1 cm
distance between each drive. The drives are mounted width wise, so that the cables
are easily accessed on the side, and that also keeps them from screwing up the
airflow.
The airflow is so strong, that you can feel it at the rear of the case like a hurricane.
The drives are almost Cold to the touch... and since the CPU is in the pathway, it too
cooled even better. It of course cools Every component in the system, including the
video card and motherboard chipsets.
My CPU temp is currently 91f in a pretty hot room... which is darn awesome for
the core2duo setup. Im using one of those monster heatsinks that has a 4" fan
mounted to it. Considering my intake fans power, I probably could remove the
cpu fan... but its always better to have redundancy anyways.
The dust flies round.. but its easy enough to blow out with compressed air
every once a year. Heck, dust can hardly settle considering the airflow I
have workin

Heat cant make it to the top of the my case! And what little might, would get sucked
out by the powersupply fans.
Only drawback is the noise levels. I will replace the main intake fans soon with
some of the new quiet tech fans. They push the same kinda air.. but are half
as loud.
Air flowing across components hot surfaces tends to do a much better job of cooling
than trying to suck air out. Air is very fluid, and not easy to suck out in a consistent
stream.. thus more times than not... you end up sucking the warm to cool air out..and
the heat remains dense in certain areas.
A good example would be to imagine sitting on a stool hovering above an electric
heater. A fan about your head isnt going to do much to keep your butt cooler. More
than likely, you will fry.. and the fan above you will pull the cooler air out.
Pointing the fan directly at you, will force cooler air over your entire surface area,
and even at the heat source, making the overall temp lower.