I use it with a PIII 733 and a radeon 7500. This setup runs all of the 2-D games like Castlevania SOTN. The 3-D ones like tekken 3 have slow down. I think it is due to the processor speed not the videocard.
Here is how to setup in MAMEWAH:
First, make a new bat file. For example: epsxe.bat. Next, open the new file with notepad and then fill it with:
epsxe.exe -nogui -loadbin %1
In Mamewah, set this file up as your emulator. Also, set ROM Extension to bin and rename all your psx image exstensions to bin. Now, Mamewah will load the command line epsxe.exe -nogui -loadbin %1 replaceing %1 with the game in your list.