Your question is pretty vague. What exactly are you experiencing?
I was setting up everithing step by step. My roms work when emulating with just mame or with the Rocket Launcher. When i endend configuring HyperHQ I selected the wheel option (HyperHQ>Wheel setings>MAME> Navifation/themes>Wheel filters> Roms Only) and tried using the Hyperspin t crashes when I select MAME.
What I noticed after unchecink this "ROMS ONLY" is that the Hyperspin doesnt crash but it wont rum my ROMs. I'm not quite sure what is happenig because I set my ROM path corectly on HyperHQ an added all extensions(7z,zip,rar,chd).
I'm using MAME 1.61 Hyperspin 1.3.3 and RocketLauncher