This problem has happened before, and I haven't figured out why, nor figured out definitively what I'm doing to fix it.
My laptop's mouse buttons act strange for no apparent reason. After logging in (where everything works correctly), Windows loads, then and somehow the left button stops working correctly. On the desktop, it takes on the function of the right button. When Windows first loads, when I move the touchpad, the screen starts showing a selection box being drawn, like I'm holding down the left button. When other windows are in focus, it doesn't do anything at all. At no point does the right button do anything. In addition, sometimes the Enter key on the keyboard doesn't even work, but only when the Start menu has been accessed. Nope, I'm not kidding, it's that specific. So I can't even use that to open things from the Start menu.
Earlier today, it happened twice. I could only get rid of it the first time when I system restored it to a point a couple days ago. It worked, then when I restarted it, it started again. When I tried system restore, it didn't work correctly, no matter how many times I restarted. So I decided to just roll back the system restores I did, and revert to when it started the fiasco today. Figured I'd figure it out later. Got tired of dealing with it. So after it restarts, my wife starts using it. And it works fine. WTF. Usually she's the bane of any electronic device at some point.
The only things I did today are reinstalled Sim City 2000 (it's Vista 64 bit), and checked with autoruns to see what was running when I had to reinstall everything. (Vista said it couldn't find the Windows files about a week ago.)
This has happened in the past, but I managed to fix it. I thought maybe a button was sticking, but that can't be it. They both still work, and I can't recreate the problem by doing it myself by holding each button in and playing around with it.
What the heck is the problem?