If you mean use the control part of the stick, there isn't one.
I expect that he means what is the best controller to hack for an interface, in which case the "go to" answer has always been the Sidewinder.
This is going to open up a can of worms, but I believe that Dave at RAM Controls is planning to offer a USB interface to his Star Wars yoke. Can't find the reference right now, but is definitely worth looking into.