Can't seem to find a resolution to this issue although I've read many posts here from others with similar problems.
Have dual Act Lab TV USB guns and have been happily using them for many light gun games through mame (area51, lethal enforcers, etc.)
Recently added the PC game House of the Dead 2 (Sega/Empire Interactive 2001 version) to my cabinet and the default settings worked well for 1 player light gun action.
However, the 2nd player gun was not configurable within the game settings and therefore useless. I did find the Troubleshooter app
http://thetroubleshooter.home.mindspring.com/games.htmwhich promised a fix for this specific issue when using the Act Lab guns.
Unfortunately, even following the directions exactly I am left with two guns that aim properly but don't register shots fired. I've given up for now but am wondering if anyone has actually made this work and can give me some pointers.