Hitting F11 will show you, in %, at what speed MAME is running the current game, relative to its proper speed.
If you're under 100%, you might get funky sounds.
Each time you hit F9, MAME will skip more frames. I'm not sure what units are used to measure how much it's skipping, but you can hit F9 to increment the skipping from 1 to 10, and then the 11th hit will set it to "auto", where MAME will try to decide, on the fly, how many frames to skip to try to keep the speed running at 100%. Of course, the downside is that your graphics & gameplay will be choppy...sometimes a little, sometimes a lot.
One other possibly useful bit of info is F10, throttle. First, hit F11 to display your %, then hit F10 to let MAME run the game as fast as your computer can possibly run it. For old & simple games, you can run games at 200-300% or more of their normal speed (can make for some fun play on slow games!), but for more modern games, you might be just barely keeping above 100% speed most of the time & then dipping below 100% during certain moments (complex graphics or sounds), which can cause slowness & stuttering.
-Jaosn