as the author of romlister, I thank you for the plug!
I'll also point you to the link:
http://www.waste.org/~winkles/ROMListerThe idea behind romlister is as such:
There is no reason to have roms on your machine that your machine is incapable of playing properly. If you don't have a steering wheel, you probably shouldn't have pole position in your game list.
If you first filter out all the games that you can't physically play, it gets to be a more manageable job to do the rest by hand, or keep filtering in romlister to weed out even more unwanted roms. You can filter by categories, screen orientation, control type, anything you want.
Check the tutorials if you get lost, or just post your questions here and I'll answer them.