I was having problems with my MAME cab running WinXP, MaLa, and BootSkin.  Wasn't sure when the issues started until I wiped the installation and installed XP on a brand new hard drive.
Everything ran smoothly and perfectly until the point where I installed BootSkin to add a finishing touch.  After the machine restarted, my BootSkin image showed up fine, and entered MaLa with no issues.  However, when I launched any MAME game at all, the games were severely slowed down.  Skipping frames, double-playing audio, etc.  Even after I removed BootSkin (which was a job in and of itself,) the issue remained.  I'm now in the process of reinstalling Windows again.  I'm not inclined to reinstall BootSkin again unless I can figure out why this is happening.
I'm using a P4 Machine with a Biostar motherboard and a gig of RAM.  ArcadeVGA AGP card for video, and an I-PAC interface.  The thing that really gets me is that I also have a cocktail MAME table that is only running on a P3/533 with 512MB RAM, and BootSkin causes no problems with MAME at all.  
The only thing I can imagine could be the problem would be an incompatibility with the P4 machine's BIOS... Would I likely run into this issue if I were to manually replace the Windows startup screen by hand?  
Worst case scenario, I can leave the logo screen as-is, and just enjoy my games.  I just really wish I didn't have to settle for the Win logo, especially when I see everything run perfectly on my P3.  Ick.
Thanks in advance,
Jeremy