Not liking the 4-way position for TB games that involve heavy jamming (Golden Tee, for example). But you can block a button with the wheel I suppose (it's higher up, I would imagine and the button wouldn't physically prevent it from going on the panel).
I still say get rid of the buttons, and move the spinner and 4-way over. But if you want them there, you'll really need to check the clearance of the wheel (take your hand into account too) when testing.