Well, following advice on here I have finally NOT ruined and/or almost killed myself drilling/cutting a sheet of Plexi.
I sandwiched the Plexi between my spade bit drilled CP and a another piece of material, used a hole saw in reverse and it worked great.
Here's the question:
I plan to through bolt my joysticks with 1/8" by 1" machine screws (1/2" MDF and 1/8 inch Plexi) but.. considering how easy this stuff cracks will the bolts being bolted to the plexi top cause it crack once it tighted down and people are beating on the joysticks?