Like the above poster said, what is it you dont like about it?
Otherwise it looks too much like the coveted "frankenpanel" that seems to be the norm around here (thankfully others have made these things so I know what to avoid).
I gather you want to be able to play many types of games on your future cab, so I will try to be succinct about the panel and guess about your "ideal" button layout.
1. get rid of all of the admin buttons (except an esc and an enter button)
2. Get rid of the 4-way dedicated. If you do it right, an 8 way will work fine. (How many 4-ways are you planning on playing? If you say "most games" then only use 4-ways or use a switchable 4-8 way)
3. If you really want the 7 button (neogeo + SF2) layout, you may want to make an inversion (IE have the 4 neogeo buttons on bottom)
4. Buy some controls off of ultimarc or Happ and make some cardboard mockups with the controls where you may think you want them. Seriously, this is the best way to do it. That way you cant get huffy about wasting a piece of cardboard...