Without any more info, I'd guess it's power, or to be more precise, the lack of.
One of the biggest problem with the TopGuns are they are power hogs, and AFAIK they need the full 500mA & 5 volts to work (and sometimes more than that at power on). Are the TB & gun trying to share a USB hub? Is the hub plugged into the wall (aka "self powered")? Or, if they're not on a hub, are they on the same USB pair? How about in the front of the computer? Sometimes the pairs, more often if in front, are like an unpowered hub, and thus can't supply the full 500mA to both ports at the same time.
Things to try:
Plug into a wall powered usb hub.
Plug into two unpaired ports in the computer.
Plug the gun into a wall powered hub and the TB direct into computer.
Plug the gun directly into the back of the computer and the TB into a wall powered hub.
Try a different brand wall powered hub (one that can deliver higher than spec mA at power on).