A lot of people think their remotes are defective when they first get them because they don't read their instruction manuals and realize you need to use the synchro button inside the battery compartment, in conjunction with a relatively hidden button on the Wii to get the controller talking to the console. My brother returned the first controller he bought, thinking it was defective. He works at Target in the electronics dept. and says that since then he's explained it to quite a few people who have returned supposedly defective Wii controllers.
If this is the case, these controllers may have been open-box, but never used. That would be a good deal indeed.