just found this post via google search.
Interesting topic especially since we play machines at home and not dependent on using whatever layout was created as heavy duty "public proof" coin-op machines in stores.
Last year, I ran into some pains due to bad ergonomics on a home-made Defender cab.
Which made me aware of proper heights and angles of the body in respect to how it is designed to function.
this year I've raised the height of the panel, added some foam layers to some buttons that require angled thumb slapping, and added some platforms to support the wrist at proper height for keeping the fingers efficiently curved.
the thing looks like a monstrosity that would never cut the mustard for durability in public, but it is now more proper and PLAYABLE.
So as the original posting brings up the topic, I think this is very interesting stuff with a group of aging classic gamers.

cheers.