I use Advanced Circuits (
www.4pcb.com) for most of my PCB fabrication needs. Their $33/ea special is almost unbeatable for the specs, and the $66/ea special is similar. If you want truely bare bones (no silkscreen or soldermask, just bare solder plated traces on FR-4), check out their bare bones special. They only accept standard Gerber files though (and maybe AutoCAD drawings, though I think they charge a fee to convert), and they do not provide layout software. Eagle CAD is a reasonably complete package that has a free version for limited stuff and isn't too expensive for the full version. Personally, I'm fond of Altium Designer, but that's BIG $$$. OrCAD is also not bad, but also BIG $$$.
There's also batchpcb, a service run by the Sparkfun guys. Turn time is VERY long and service isn't nearly as good, but it is a fair bit cheaper, especially in low quantity for small boards.
If you've never done this before, it's a big project. Taking something from "I want a device that does this" to a complete physical device that does that involves lots of skills that take a little while to pick up. You need to know at least basic circuit theory, how to program very small "computers" (microcontrollers), and you'll need to be able to solder (or spend big $$$ to get the boards assembled for you).
If you have some oddball interface requirement, I specialize in that kind of thing. I've hooked up beatmaniaIIDX cabinets to playstation2s in the past, so I'm reasonably confident that I can get done just about anything you'd need. If you just want to hook some buttons and a joystick up to a playstation, go hack a $5 digital pad from gamestop - it's way cheaper, unless you just can't stand the ugliness (I can't). PM me if you're interested.