I have only cut 1/8" but should work the same on 1/4". I use a forstner bit to drill a pilot hole so I can get my laminate router bit in the hole. Then I use the hole drilled in the cp (mdf, particle board, ply, etc) to finish the hole and clean up all the melted plexi from drilling. Just go real slow when you are drilling and make sure your router bit isn't touching the side when you start it.