Here's the scoop as to my problem.
I'm making a modular control panel, similar to jelloslug's design. Thus, I'm going to be able to swap out joysticks, track balls and button banks at will.
I'm trying to allocate how I'm going to set up my I-PAC to handle this all. After reading over jelloslug's page, I was inspired by another one of his ideas.
I plan to take the first 24 inputs on the I-PAC, and divide them up into 4 sets of 6. Then, wire those 4 clusters onto quick-disconnects (most likely some hacked up DB9 extension cords).
Two of the 4 would be set up for joysticks. While most joysticks need only 4 inputs, those with triggers need 5, and 12-point rotary ones connected to an interface card need the full 6. The other two would be configured for buttons, with a max of 6. I was planning on making several button banks (Street Fighter 6 - red-white-blue, Mortal Kombat 5 pattern-block in center, Neo-Geo 4 different colored all in a row, etc)
Optical junk like spinners and trackballs would connect to an optipac and use different connectors, thus saving me some pain.
Now, the last 4 inputs on the I-PAC, I was going to perma-wire as 1-UP, 2-UP, Coin 1, Coin 2... but I also want to add a quick-hit pause button at the top of the cabinet just under the marquee, problem is, where to wire it. Thus, back to my original question.
I knew of the "shift" functions on the I-PAC, so I was wondering if wiring the pause button across the two leads in parallel would work.