Go ahead an try it. If you're using Mamewah, I recommend using it's res tool, as it seems to work differently (behave better might be a better way to describe it) with it. An added benefit of this tool is it only creates ini's for the games you have, so (unless you have the complete rom complement) if you want to mess with them, it's easier to get at 'em...though, even easier, is that you can mess with them with the tool, itself. The Benson tool, I think, only generates them - though it's easier to generate ini's with.
Although, I'm thinking the reason no one answered is cos they thought, 'jus try it'.