My thoughts on this one are as long as you don't pull more current through the USB / PS/2 port than it it is able to deliver, you should be fine.
With non-powered USB ports, this is up to 500 ma (before any devices are factored in.)
So I don't see any problems with 2, 4 or 8 LED's being powered from the 5v line on the interface, unless you have an LED-Wiz on the same port with a bunch of LEDs being powered by it.
As mentioned before, make sure you use the correct resistors for your LEDs or else LEDs = junk

RandyT