I did a lot of cutting today!!! Wow, I think it looks great, and I didn't even remove the stuff from the protective wraps!

I cut the control panel's basic shape the day before with the plex-glass cutter. (followed your advise and made many scores, going almost right through).
I bought a flush trimming bit with a 45 degree angle to it. I mounted the plexi to the CP and routed right around it. Snow flakes everywhere...but it went very smoothly! I was surprised and proud!

I flipped the thing over and used the holes in the cp as guides for the plexi, but I just used the same hole saw I did for the wood. Again, it went quite smoothly.
The trackball and spinner holes were a bit more tricky, but not too hard. The router with a flute bit and some sand paper did the job.
(Also routed out the joystick, spinner, and trackball bases while I was at it!)
Wow, can't believe how much I got done! Thanks for the help.
Next step: find some place to print the artwork and marquee I made/downloaded. Quick question:Do I just lay the artwork down and then cut the holes out with an exacto-knife? Do you glue it down?
Thanks again Arcadelites,
~Mrbond