Here is a truly bizzare thought that gives new meaning to the term "keyboard hack":
If the keyboard controller is a separate daughtercard, as it usually is, the rest of the keyboard is just traces and switches with no electronics. So theoretically, if you had a keyboard with an actual circuit board and switches (as opposed to a membrane with rubber actuators), you might be able to cut off the keypad and utility keys (Insert, Home, End, cursors, etc.) with an xacto saw. You'd have to plan ahead and follow the traces you would be cutting, as you'll need to solder a jumper wire from those traces to the spot on the keyboard controller matrix where they're destined (and possibly back to the piece you're keeping if the trace doubles back). If you cut off the end of the ribbon cable that goes to the keyboard, separate and strip the lines and run them to barrier strips, it should be pretty easy. If you really carefully mapped out the whole thing, you should be able to cut off the function keys too and you have nice little sets of four keys to play with. And if you accidentally map the wires to the wrong place on the controller, odds are the worst that will happen is that it reads as a different key.
The trouble is doing this in USB; most keyboard with actual circuit boards and switches are likely to be standard keyboards, as I don't know of any recent keyboards that use real circuit boards under the keys.
Am I being an idiot, or should this work?