Well ask yourself this one question: "Do you enjoy playing video games at a 45 degree angle to the TV?". If you answered "No", then you will hate your layout down the road. Facing the display straight on is always the best, and an angle is really only tolerated for those oddball 4-player games.
Secondly, I would avoid (running and screaming) 'mirroring' controls. Player 1 and 2's layout should always be absolutely, positively identical (joystick on left, same number of buttons) lest you be accused of giving yourself a handicap in SFII or similar simo-2p game.
However, I do like the rounded CP approach and you should definately keep that!
My advice: lay out your joysticks in the most comfortable manner, giving it priority, then work your other controls around it. Because, unless you're a 4-way game junkee, those joysticks get the most play out of any of those other controls.