This could be the result of a ground loop somewhere in your system or feedback through an inexpensive on-board soundcard.
The first thing I would try is to open up your mixer through your Volume Control properties and mute all unnecessary inputs - i.e. Line-In, Aux, Microphone, etc. This may help you isolate where it's coming from.
Can you provide more details as to what your system looks like and how it's being used?
Whoops - my bad! I didn't see that this was related to a specific upright cabinet. My apologies, although it is possible that there is a ground loop somewhere in your audio path. I wouldn't be able to help you troubleshoot it without seeing a schematic of how the cabinet is wired.