>>you will be able to calibrate the topgun so just "see" the 2nd monitor
Are you implicitly saying that this can be done, or do you not know?
>>I assume when using a mouse in windows, you can move across both monitors in one motion
You assume correctly. But, the vertical position is not relative. The primary monitor runs at 1280x768, and the secondary monitor runs at 1600x1200. If the mouse cursor is on the primary monitor at the very bottom, 768 pixels from the top, and I move it to the right, it will emerge on the left side of the secondary monitor 768 pixels from the top, a bit below midway. If the cursor is on the secondary monitor and is more than 768 pixels below the top, and I move it to the left, it will not cross over.
>>If I recall, when using a mouse in lightgun games on a dual monitor setup, while mame has "focus", all movements of the mouse are restricted to the second monitor where mame is - you physically can't get the mouse pointer to appear on the primary monitor.
That is consistent with my observations.