Running your cab open is only acceptible if you're using a PC inside it's case, and especialy a CASED monitor. If you got an open (arcade) CRT monitor I would strongly suggest NOT to leave the cab open.
If I take my back panel off, the mains is cut off by the safety switch, LIKE IT SHOULD !!!
I bought an original arcade JAMMA cab, and this has the mains "safety switch" still in place and working.
If you're running an open CRT inside your cab, leaving the panel off makes the 25.000 Volts to be in direct reach of touch. Nasty, but really dangerous are the couple of hundred volts to be found everywhere on the chassis of the monitor.
Of couse you will never touch this. That's the same reason why you're not wearing seatbelts, you're not ever going to get into an accident right ?
I'd never suggest this. It is very unsafe, even if you "can't reach" inside. I've got a 4 year old kid running around, even playing the cab sometimes, wouldn't want him "exploring" the inside of my cab !