I have used Mame32 in the past for my arcade which outputs to a 27" television. I had to tweak the GUI a bit so that it was more readable. I increased the fonts and make them bold. This way it is just as easy to read than other front ends.
But after seeing some of the other frontends out there, you quickly realize that the Mame32 GUI detracts from making your arcade cab look like an arcacde cab.
It looks like a windows computer. (ok it is....but that doesn't mean you have to look like one).
MameWah and GameEx are the ones that I've tried that look the best. Plus I love the feature of having movie previews of the games instead of just snaps. Also both of these frontends will allow you to run other emulators (mainly for me Daphne, Project64 and just PC Games).
While Mame32 is great and makes it so that you're ready to run in a few seconds, the other two frontends have a few drawbacks mainly due to ease of setup.
MameWah's main drawback is that it is a ---smurfette--- to setup for noobies. There's lots of resources out there for help plus now there's MameWahConfig which is like a godsend for me.
GameEx while looking the sleekest does require some extra time setting it up (but its not that bad) and it takes a bit more resources while running than the other frontends (but I guess it takes more cycles to look that nice).
Well, I'm not sure if that helped you or not...
Just my $0.02 worth.
Good Luck