As someone who has put on wheels on the cabinet, I say that I *love* it for now. My cab has a removeable back panel and I need to access it all the time. It's in my garage and it would be a pain if I had to move it all the time. It's stored about 2" away from the wall. It's easy for me to move it when I want to. When I'm playing, the motions are so localized, I don't have to worrry about it moving. The only thing that sucks is that the cabinet is about 2" - 4" taller due to the wheels (can't remember what size they are).
If you do put wheels in without any framework, go buy the metal electrical box covers , one for each wheel or you can over-engineer it (like me) and buy 2. Take the wheels and go to a metal mfg shop. Pay $20 to get holes drilled. [I suck at drilling and would rather toss money at the situation for someone to fix it.] Put the cabinet on its side and drill. My cab is flat on top and back, so I just can't lay it down and pick it up easy. I fabricated a "stand" from 2" x 4". I don't have any pictures, but think of those realtor "For Sale" signs. Put the long piece on top of the short on. The long piece will hold the edge of the cabinet when on the ground so you can still access the inside. The short piece will be on the side of the cabinet.
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That's what I did...
[Edit] When you go to the metal shop, have them drill holes in the plates, not the wheels.